Chapter 1066: Good Luck (First two chapters, one more chapter)
"Mold?" Professor Qi, who was discussing the experimental process and plan with Lou Xiao'e, who took some time to come over from the chest surgery department, looked confused.

Isn't it normal to have mold? Is it worth making such a fuss? It's only been a short while since we started screening bacteria. Which culture medium is not moldy?

In fact, Klebsiella and mold are not the same thing, but this is a common convention.

wrong!

This graduate student was selected by me personally, so he would definitely not behave so impatiently. Did I hear it wrong?

Lou Xiao'e was the same. She glanced at Professor Qi and her eyes lit up: "Professor Qi, did Junior Sister mean 'no more'?"

there is none left?
Following Lou Xiao'e's suggestion, thinking about the next part of the conversation, and combining it with the behavior of the junior sister who burst into the door with a "thump", Professor Qi seemed to understand something.

"It's really not moldy anymore?" Professor Qi said excitedly, grabbing the little sister's hand.

"Yes, yes! There is a piece of culture medium, and around the point where the extract is injected, there is really no mold, it's completely clean!" The junior sister was jumping up and down.

But this kind of jumping up and down was not out of anger, but out of excitement and liveliness.

The three female generals looked at each other, unable to suppress their emotions.

You wanted to find a needle in a haystack, but you didn't expect that you could find it easily?

"Let's go! Let's take a look!" Professor Qi pulled two students and rushed straight to the laboratory.

At the door of the laboratory, the three of them changed their clothes while looking eagerly through the glass at the pile of jars and cans in the culture room, without caring about any communication.

Although they were anxious, the three of them were very careful and methodical in changing clothes. They couldn't be chaotic at this time, as chaos might lead to losses.

Some of the various microorganisms here have sources that are easy to identify, while others are not so easy to identify. There is a possibility that you will miss it forever.

The three of them changed their clothes and carefully checked each other. Then Professor Qi nodded, took a deep breath, and said to his two students: "Let's go in!"

The three of them entered the culture room and, under the guidance of Junior Sister Xiao Luo, went straight to the precious culture dish.

Sure enough, in this culture dish, there were several holes on the surface of the culture medium that was full of Klebsiella, and there were no bacterial plaques or hyphae, just like there were several holes in the cloudy sky, and the sunlight was shining straight through the holes onto the ground.

Although the holes were not emitting any light at this time, in the eyes of several people, it was as if beams of sunlight were shining into their eyes. This was hope.

"Really not, really not..." Professor Qi was very excited and muttered to himself, this may represent a new path for antibiotics. Although it is an improvement on the original antibiotics, you can only say whether it can have a certain impact on drug resistance.

However, Professor Qi still maintained a certain rationality: "Is it OK under the microscope?" Only if there is no problem under the microscope can it be said to be really OK. After all, sometimes it looks fine to the naked eye, but it may be another matter under the microscope.

Although similar research in this era did not use all kinds of weapons like the ones decades later, at least the basic conditions, standards and systems were in place. A hot piece of knowledge is that after the penicillin factory built with Russian aid went into production, we became the country with the largest penicillin factory in Asia.

"Not yet. I just saw that there was no mold, so I ran out to call you. I haven't had time to check it under the microscope yet." Junior Sister Luo was a little worried. Could it be that she was happy for nothing?

At this moment, their mood was a bit like the feeling of being homesick.

"Don't panic, don't panic. No matter what, this culture medium is different from the others. It's something worth being happy about and studying. Examine it under a microscope, immediately!" Professor Qi made the final decision.

"okay!"

Junior Sister Luo acted quickly. Ten minutes later, she looked up from the microscope and said, "No, really not!" in a cheerful tone.

Professor Qi and Lou Xiao'e looked at each other and thought, this is a sure thing!
"Which group?" There are many microorganisms involved in the screening.

Junior Sister Luo looked at the mark on the petri dish, flipped through the experimental records, typed a few words on the computer, and looked at Lou Xiao'e with admiration.

"Senior sister, you are amazing! It's the Streptococcus clavulogensis you specifically requested!"

Lou Xiao'e was a little confused, but also a little embarrassed. Our Zhendong is really a lucky guy. He just gave an example casually and hit the nail on the head?

She didn't think that Gao Zhendong had already researched this and told her about it on purpose. This thing was too far away from Gao Zhendong's own field and it was impossible.

Even if my husband and I had some understanding of it when we were writing the "Concise Manual for Primary Care Physicians", it would be impossible for us to come up with research results directly, and I have never seen him conduct related research.

Despite this, Lou Xiao'e still does not take credit for it. Doesn't a lucky person also have the right to take credit for it?

"This was an example my wife mentioned when she was helping me design a screening test. The name of this fungus is quite special, so I remembered it. I didn't expect it to be this one!" Professor Qi and Junior Sister Luo were dumbfounded after hearing what Lou Xiao'e said. Is this even possible?
They didn't know much about Lou Xiao'e's marital status. Professor Qi was shocked and asked, "Xiao'e, is your husband also doing microbial research?"

Otherwise there is no way to explain it.

Speaking of this, Lou Xiao'e was very proud, even prouder than when she was praising herself: "No, no, he is from the 17th Ministry of Machinery. He is indeed very good at his profession, but he only has some superficial understanding of microorganisms. You know my book, right? He helped me collect the information. But for this fungus, he must have been lucky, hahaha~~~~~"

Zhendong has definitely not done any relevant research. There is no other explanation except luck, otherwise it is unscientific.

Gao Zhendong: This is indeed unscientific.

Seeing Lou Xiao'e smiling like a silly girl, Professor Qi couldn't help but sigh that Lou Xiao'e was really lucky, in every sense of the word. She knew Lou Xiao'e's background. Not to mention that she went from Beijing Second Medical College to this school, even the fact that she was able to attend Beijing Second Medical College was a matter of fact.

As for Junior Sister Luo, she was only deeply envious. Does her brother-in-law have any brothers? Introduce one to her. If not, a fellow junior brother will do.

"Never mind whether it's luck or not, we have found a substance that can inhibit Klebsiella, which is a major breakthrough! Thank you, my love, anyway."

Professor Qi is very rigorous. Although there is indeed no Klebsiella around here, the reason and mechanism still need to be studied.

It is possible that a new antibiotic was produced by Streptomyces clavuligerus, but it is still unclear whether this antibiotic can be used in humans. There are a lot of natural penicillins, but only penicillin G and penicillin V can be used in humans now. The former is used for injection, but is unstable, and the latter is used for oral administration, but the efficacy is not as good as the former.

If this is the case, it is hard to say whether this new antibiotic can be used in humans and whether its antibacterial spectrum is broad, but it is at least a new approach.

As for Professor Qi and the original intention of screening this strain, they hoped that it was because of the idea proposed by Lou Xiao'e - this bacteria secreted a certain substance and died together with β-lactamase, and then the penicillin in the culture medium took effect without the influence of β-lactamase.

In that case, as long as this substance is non-toxic to humans or its side effects are within an acceptable range, it may serve as a guard for penicillin, allowing penicillin to deal with pathogens whose main means of resistance is β-lactamase. To some extent, that may be more convenient than developing a new antibiotic.

So what Professor Qi wants to know most now is what the mechanism of this thing is.

"Okay, teacher. Let's start studying its mechanism of action right away. What about other bacteria?"

Professor Qi thought about it and said decisively: "Let's not do it. Our resources are limited. Let's study this clavulose Streptomyces first. If there is no way to find this clavulose Streptomyces, we will restart the strain screening work. And..."

"And what? Teacher Qi."

"Moreover, the source of this rod-shaped streptococcus is our own soil sample, which can withstand more test. At least the source is not that difficult." This is our own stuff, so we can be much more relaxed.

If there is any progress, we might as well dig deeper into the ground where the samples were taken. Maybe we can make other discoveries.

At this time, Professor Qi demonstrated her rich experience in this field and her decisiveness in making decisions. Since the conditions were limited, she could only do it according to the limited conditions.

The phrase "the road ahead is rough and tattered" is far from being as easy as it seems.

Lou Xiao'e and Sister Luo looked at each other and nodded together: "Okay!"

When Gao Zhendong returned home from get off work, he was greeted by Lou Xiaoe's charge.

Lou Xiao'e rushed up, hung around his neck, and kissed him on the face.

"Hahaha, you're amazing!"

Gao Zhendong didn't understand, but he had to brag: "Of course, I'm awesome. By the way, what's so amazing about me?"

Accept the daughter-in-law's compliment first, and then ask what the matter is.

"We have conducted culture tests and tests on many kinds of microbial extracts, but we have never found the situation you described..."

Gao Zhendong was not surprised at all. This was too normal. It was not uncommon to screen bacterial strains for a lifetime.

"But! But, that Streptococcus aureus you mentioned really worked! This bacterium came from domestic soil samples. Now our Professor Qi has decided to dig deeper along this path." Lou Xiao'e slapped Gao Zhendong in the face again, which was considered a reward.

"Ah? So fast?" Gao Zhendong was also a little surprised. He didn't even know where the Streptococcus came from, and thought it would take them a long time to get it. Unexpectedly, it was a soil sample produced in China.

Lou Xiao'e always felt that Gao Zhendong's words were a little strange, but she couldn't tell what was strange about them. She could only explain it as Gao Zhendong expressing his amazement at their rapid progress.

(End of this chapter)